Figure 1: Main functions of the lysosome and their relationship with key cellular processes. Lysosomes are involved in the degradation and recycling of intracellular material (via autophagy) and ...

Lysosomes are dynamic organelles that receive membrane traffic input from the secretory, endocytic, autophagic and phagocytic pathways. They can also fuse with the plasma membrane. Live-cell ...

“If something happens and a molecule grows in abundance 200-fold in the lysosome, you would see only a two-fold increase if you look at the whole cell.” By isolating lysosomes from the rest of the ...

More information: Kangfu Peng et al, The autophagy protein ATG-9 regulates lysosome function and integrity, Journal of Cell Biology (2025). DOI: 10.1083/jcb.202411092.

Scientists uncover novel function of autophagy protein ATG-9 in regulating lysosome integrity. Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste ...

Skip to main content. Scientific American. December 1, 2016. ... It also seems to be involved in life span and longevity; studies have shown that when lysosomes do not function properly, ...

Skip to main content Ready to start planning your care? Call us at 800-525-2225 to make an appointment. Sloan Kettering Institute. MSKCC.org Home ... Lysosome function, dysfunction and human disease.

“What’s beautiful about this system is that all of the components of the PITT pathway were known to exist, but they weren’t known to interact in the sequence or for the function of lysosome repair,” ...

The big challenge now is to show that granulins function in lysosomes, and what they do there, he said. Paired for Processing. Progranulin (green) and cathepsin L (red) meet up in Lamp2-positive ...

In the April 15 Developmental Cell, they reported that knocking out presenilin 1 and 2 in mouse fibroblasts causes APP-CTFs to accumulate in lysosomes, especially at junctions with the ER. This ...