Live-cell imaging has shown that lysosomes interact with late endosomes by 'kiss-and-run' events and by direct fusion. Fusion results in the formation of hybrid organelles, in which the ...

In summary, we propose that mitochondria–lysosome contacts are regulated in two steps: formation and stabilization of contacts promoted by lysosomal GTP-bound RAB7, followed by contact ...

Snatches of the conversations shared by mitochondria and lysosomes have been “heard” by scientists, who speculate that the organelles are exchanging regulatory tips. Mitochondria appear to ...

The autophagic pathway proceeds through several phases, including initiation (formation of a preautophagosomal ... and autophagosome–lysosome fusion. In the final stage, autophagosomal contents ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged organelles, and unwanted molecules using powerful digestive enzymes.

2006; Maeda et al., 2007), and they are viewed as potential seeds for fibril formation. “Some people think the oligomers are more toxic than aggregates, and we do see in vitro that they will break ...

Neither is it clear how lysosome accumulation may be related to ... These animals produced more Aβ and formed larger amyloid plaques, surrounded by an increased number of swollen axons.

By using video microscopy with fluorescent tagging of the two organelles, the scientists observed that the mitochondria and lysosomes formed stable contacts inside living human cells. The authors ...

a process by which new functional lysosomes are formed from mature lysosomes. Here, the team found CLN3 is critical for the generation of new lysosomes, by impairing both de novo lysosomal ...

On fusion with lysosomes, the enclosed material is degraded by lysosomal enzymes in autolysosomes. Formation of the autophagosome in mammalian cells is initiated by a protein kinase complex ...

ApoE lipidation promotes microglial uptake; delipidation in lysosomes may goad aggregation. Gobs of these intra-lysosomal deposits formed when lysosomes were hobbled with inhibitors, or when ...

The lysosomes that get stuck and accumulate inside ... These animals produced more β-amyloid and formed larger amyloid plaques, surrounded by an increased number of swollen axons.