Rabbit polyclonal antibodies against AKT, pAKT (Ser473), caspase 3 and 9, Cbl, JAK2, pJAK2(Tyr1007/1008), Lyn, pLyn(Tyr396), Hck, and PARP, PI3K p85 STAT5, pSTAT5(Tyr694), were obtained from Cell ...

Taken together, we showed that knockout of PDK1 indirectly alters the PI3K/PDK1 signaling axis by regulating gene transcription of Lyn, PI3K subunits and phosphoinositide-modifying enzymes.

HOUSTON -- Two-thirds of patients with PI3K-mutant brain metastases responded to the maximum tolerated dose (MTD) of the small-molecule inhibitor paxalisib plus radiation therapy (RT), a small ...