2025年ASCO会议入选的这5项壁报研究聚焦于淋巴瘤的免疫逃逸、关键基因突变、肿瘤微环境及治疗策略优化，为淋巴瘤的精准治疗和个体化治疗提供了重要的理论依据和实践指导。这些研究成果不仅深入剖析了弥漫大B细胞淋巴瘤（DLBCL）和滤泡性淋巴瘤（FL）的关键生物学机制，还为临床治疗提供了新的视角和策略。

The search for alternative treatments led to the finding that the phosphatidylinositol-3-kinase (PI3K) pathway that controls cell metabolism, growth, division, and survival and allows the cells to ...

leniolisib有潜力为活化的肌醇磷脂3-激酶δ综合征（APDS，一种原发性免疫缺陷）治疗带来一款疾病修正靶向疗法。 乳腺癌是一种恶性疾病，每八名女性中就有一人会在一生中患病(12.9%的终生风险)。由于其细胞和分子的异质性，这是至关重要的，以了解驱动乳腺癌 ...

The content of ATP in cells was measured by ELISA method. The expression of HIF-1α protein and the expression of PI3K, AKT, p-PI3K, p-AKT in PI3K/AKT pathway were detected by Western blotting. The ...

Phosphorylation of CD19 leads to the membrane recruitment of phosphatidylinositol 3-kinase (PI3K) and activation of Akt, which phosphorylates downstream proteins leading to their inhibition [red (P)] ...

Activating mutations involving the PI3K pathway occur frequently in human cancers. However, PI3K inhibitors primarily induce cell cycle arrest, leaving a significant reservoir of tumor cells that may ...

Deficiency in Gβγ binding, significantly reduced rates of proliferation while p110β-Lyn RBM supported growth comparable to p110β-Lyn (Figure 5A). Signal transduction via the PI3K pathway requires a ...

目前已被发现能诱导人角质形成细胞和成纤维样滑膜细胞（FLS）的增殖，从而导致自身免疫性疾病的发生如牛皮癣、类风湿关节炎（RA）等。这些疾病的特点就是会角质细胞和滑膜增生。 PI3K/Akt/mTOR信号级联在细胞生长和存活中起着至关重要的作用。

Find more information on the Altmetric Attention Score and how the score is calculated. Inhibition of phosphoinositide 3-kinase (PI3K) signaling is an appealing approach to treat brain tumors, ...

Various isoforms of PI3Ks exist, including the delta (δ) and gamma (γ) isoforms, which show a preferential expression in cells of the immune system. The use of PI3K-δ inhibitors such as ...

Rabbit polyclonal antibodies against AKT, pAKT (Ser473), caspase 3 and 9, Cbl, JAK2, pJAK2(Tyr1007/1008), Lyn, pLyn(Tyr396), Hck, and PARP, PI3K p85 STAT5, pSTAT5(Tyr694), were obtained from Cell ...