Aging is associated with significant changes in hematopoiesis that include a shift from lymphopoiesis to myelopoiesis and an expansion of phenotypic hematopoietic stem cells (HSCs) with impaired ...

Conclusions Prolonged depletion of B cells in patients with AAV after RTX therapy indicates a B-cell defect that is unmasked by RTX treatment. Our data indicate that impaired bone marrow ...

aDepartment of Immunology, School of Medicine, UConn Health, Farmington, CT, 06030, USA bCenter on Aging and Department of Genetics and Genome Sciences, School of Medicine, UConn Health, Farmington, ...

We also performed bone marrow transfer, single-cell and bulk RNA sequencing. We have demonstrated that UBXN3B is essential for B lymphopoiesis from the precursor B stage in the bone marrow and ...

In patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), a profound dysregulation of the B-cell compartment, along with disturbed central B-lymphopoiesis and nearly ...

However, the molecular mechanisms driving these alterations remain poorly defined. Using mouse models of ALL and AML, here we show that leukemic cells turn off lymphopoiesis and erythropoiesis shortly ...

CHD4 is required for IL-7 receptor signaling and efficient V(D)J recombination. Furthermore, CHD4 is essential for repression of non-B lineage gene transcription during B lymphopoiesis. Together, our ...

Mechanistically, we identified stroke-induced glucocorticoid release as the main instigator of B lymphopoiesis defects. B-cell lineage-specific deletion of the GR (glucocorticoid receptor) in CD19-Cre ...