First, both the Arimidex-Nolvadex (ARNO) 95 and ABCSG-8 trials, which transitioned patients from tamoxifen to an AI after 2 or 3 years, demonstrated survival advantages, as did a meta-analysis of ...

Anastrozole is an antiestrogen compound that inhibits aromatase, an enzyme that catalyzes the formation of estradiol from testosterone. 107 Anastrozole is currently used as an adjuvant in ...