Figure 4: Schematic of a pathway that characterizes a therapy-resistant mesenchymal cancer cell state and its dependency on lipid peroxide dissipation. Dysregulation of the apoptotic cascade is ...

a mitochondrial enzyme that normally is involved in the pyrimidine biosynthesis pathway. In cells with low GPX4 expression, loss of DHODH activity led to the accumulation of lipid peroxides in ...

This pathway centers on the synthesis, storage and use of long-chain polyunsaturated fatty acids, which are susceptible to becoming reactive lipid peroxides. During the process, GPX4 breaks up ...

Announcing a new publication for Acta Materia Medica journal. In addition to regulating lipid biosynthesis and uptake, sterol ...

such as proteins and lipids. That is why we were amazed to find that in cells lacking either glutathione or glutathione peroxidase 4, a distinctive signaling pathway is engaged, which causes cell ...

The results indicate that the complexity of sterol metabolism could have resulted from the need to balance lipid interactions required for membrane organization "This has been one of my favorite ...

Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say. Holly Barker is a freelance journalist ...

UT Southwestern researchers have discovered a molecular pathway that allows cells to sense when their lipid supplies become depleted, prompting a flurry of activity that prevents starvation. The ...