Lipid peroxides are oxidative degradation products ... Ferroptosis is regulated by amino acid metabolism. Here, authors show that the methionine-SAM-UQ axis is responsible for mtROS generation ...

Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say. Holly Barker is a freelance journalist ...

Human cells have 25 different selenoproteins. These antioxidant enzymes help convert dangerous ROS, such as lipid peroxides, into a safer form. Buildup of lipid peroxides can affect critical cells ...

The research team discovered that activation of this stress pathway, known as the integrated stress response (ISR), prompts microglia to produce and release toxic lipids. These lipids damage ...