Northwestern Medicine scientists have developed a promising approach to killing treatment-resistant cancer cells by exploiting their hidden metabolic vulnerabilities, according to a study published in ...

GPX4, Glutathione Peroxidase 4; LOX, Lipoxygenase; POR ... Ferroptosis represents a unique intersection of lipid metabolism, oxidative stress, and iron regulation, offering fresh insights into cell ...

The excess non-covid mortality currently seen is due to cardiovascular disease. The following pathway for primary care clinicians has been developed to provide clear and simple guidance on how optimal ...

Changes in lipid metabolism are critical for the regulation of ferroptosis and thus have important roles in cancer therapy. In this review, we introduce the characteristics of ferroptosis and briefly ...

1 Departments of Biological Sciences, Tennessee State University, Nashville, USA. 2 Departments of Chemistry, Tennessee State University, Nashville, USA. Lipid peroxidation is a complex process ...

Figure 4: Schematic of a pathway that characterizes a therapy-resistant mesenchymal cancer cell state and its dependency on lipid peroxide dissipation. Dysregulation of the apoptotic cascade is ...

Accumulation of lipid peroxides in the cell are associated with diseases and cellular stress. In a new study, researchers show that lipid peroxides also play an important, yet unrecognized ...

Prior to this study, scientists had already established that accumulation of lipid peroxides* indicate cell stress. Lipid peroxides have further been shown to be very potent inducers of cell death.

5B). The key components of this pathway include 12/15-LOX- and Gpx4-regulated formation of peroxidized lipids, which inhibit PTPs and thereby increase RTK signaling. Increased levels of peroxidized ...