The concept of 'bioactive lipids', or lipids that activate specific signaling pathways, has been slow to take hold in the biochemical community, as lipids have traditionally been viewed as energy ...

When growth of the labile iron pool exceeds the buffering capacity of ferritin (noncanonical pathway) or when formed lipid peroxides are not cleared properly (canonical pathway), excessive lipid ...

Northwestern Medicine scientists have developed a promising approach to killing treatment-resistant cancer cells by exploiting their hidden metabolic vulnerabilities, according to a study published in ...

Graphical Abstract. Effects of lipopolysaccharide (LPS) exposure on white adipose tissue (WAT) lipid metabolism during endotoxemia in a dairy cow model. The timeline highlights the biphasic response: ...

This work was supported by a V Foundation grant awarded to C.S.T. (T2022-018). S.M.L. was funded by a T32 Physical Genomics Training Fellowship (T32GM142604) and the Dr. John N. Nicholson Fellowship ...

These quinone antioxidants function as radical scavenging agents that prevent the propagation of lipid peroxidation and the induction of ferroptosis. Although several small-molecule inhibitors of FSP1 ...

Triple-negative breast cancer (TNBC), an aggressive malignancy with limited tools to predict recurrence and drug sensitivity, exhibits ferroptotic heterogeneity across subtypes. However, the tumor ...

Hallmarks gene set enrichment analysis was utilized the “irGSEA” R package (v2.1.5). The ssGSEA algorithm was utilized to conduct differential pathway score between ferroptosis-related immune cell ...

The formation of vascular plaques is a complex process involving the interaction of plasma lipids with the vascular wall and immune cells ... and subsequently by glutathione peroxidase 1 (GPx1) to ...

The blood from the slaughtered chickens was collected in plain bottles for serum biochemical indices (total protein, aspartate aminotransferase, alanine aminotransferase, cholesterol, and creatinine) ...

† School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China ‡ Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China Article Views are the ...