and lamin B receptor (Lbr) are essential for holding silent genes in their correct position at the edge of the nucleus, in the form of heterochromatin. A deviation from their normal position will ...

“This exciting paper is relevant to AD and related tauopathies, where we see a general loss of heterochromatin and alterations in the lamin nucleoskeleton,” Bess Frost, University of Texas Health, San ...

They disrupted the gene encoding CEC-4, the protein that anchors heterochromatin. The loss of this protein was sufficient to suppress all the phenotypes correlated with the mutant lamin ...

"In the course of differentiation, there is a switch from the LBR to lamin A/C, and there is always a least one type of tether available for attachment of heterochromatin to the nuclear periphery.

and lamin B receptor (Lbr) are essential for holding silent genes in their correct position at the edge of the nucleus, in the form of heterochromatin. A deviation from their normal position will ...

ZMPSTE24 protein expression during murine aging. ZMPSTE24 protein levels were determined by Western blots from brain, liver, heart, gastrocnemius, and subcutaneous fat of young (9 months of age, n ...

Lamin heart disease is a genetic condition that affects the heart's ability to pump blood and can cause life-threatening abnormal heart rhythms. It is caused by a mutation in the LMNA gene ...

"In the course of differentiation, there is a switch from the LBR to lamin A/C, and there is always a least one type of tether available for attachment of heterochromatin to the nuclear periphery.