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为解决mRNA疫苗诱导的CD8+ T细胞应答短暂且缺乏组织驻留记忆的问题，Aunins团队通过将IL-12 mRNA-LNP（LNP–IL-12）与抗原mRNA共递送，显著增强了CD8+ T细胞的扩增、效应功能及记忆形成，并在李斯特菌感染和黑色素瘤模型中验证了其保护效力。该研究为优化mRNA疫苗设计 ...

Climate models are essential tools for understanding our planet's future, helping scientists predict global warming patterns, sea level rise, and extreme weather events. These sophisticated ...

The principle of least privilege access comes down to less is more; the less access provided, the more secure. It’s a subset of zero trust security and an important part of a solid access control ...

Last week, Chinese lab DeepSeek released an updated version of its R1 reasoning AI model that performs well on a number of math and coding benchmarks. The company didn’t reveal the source of the ...

The Association supports the news industry including WITF and LNP|LancasterOnline. “Journalists have a constitutional role to perform,” Melewsky said. “Barriers to access and delays to ...

Maggie Allen, Cocalico; Ally Breneman, Lampeter-Strasburg; Victoria Kolawa, Warwick; Milani Ly, Garden Spot; Emma Tollaksen, Elizabethtown; Emma Trout, Lancaster ...

The polarizer consists of new structure printed on a RT-5880 substrate. In order to decrease size of traditional design of Jerusalem-cross, a ring is used in the center of FSS. The polarizer provides ...

Orient the bulb and your eye so you can see the reflection of the bulb in the plastic. Look at the reflection through a piece of polarizer. Rotate the polarizer and vary the angle at which you look at ...

Rotating the polarizer as you view the patterns makes the colors change. With a little creativity, you can also create colorful renditions of objects or scenes. Tools and Materials Transparent tape ...

为解决LNP-mRNA经振动筛雾化器（VMN）雾化后理化性质不稳定的问题，研究人员系统研究了高频率网格振动（HFMV）和惯性撞击对LNP-mRNA粒径、多分散指数（PDI）、zeta电位（ZP）和包封率（EE）的影响。结果表明，HFMV导致LNP-mRNA粒径显著增大（215–363 nm vs. 116–130 nm ...