aBeijing Key Laboratory of Cell & Gene Therapy for Solid Tumour, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Early Drug Development Centre, ...

Cells adopt a continuum of states, representing cellular activities such as the cell cycle or responses to stimuli (Kotliar et al, 2019; Xia and Yanai, 2019).Labelling cells only by type thus does not ...

Amgen has detailed a positive phase 3 readout for its T-cell engager Imdelltra in previously treated small cell lung cancer (SCLC). The DLL3xCD3 bispecific has shown that it can help patients live ...

Tarlatamab, a bispecific delta-like ligand 3–directed T-cell engager immunotherapy, received accelerated approval for the treatment of patients with previously treated small-cell lung cancer.

While immunotherapy has revolutionized treatment of many solid tumors, immune checkpoint inhibitors have generally failed to demonstrate clinical utility in prostate cancer (PC). 1,2 T-cell engager ...

In a phase 3, randomized trial, we enrolled patients with local or regional cutaneous squamous-cell carcinoma, after surgical resection and postoperative radiotherapy, at high risk for recurrence ...

To develop a model that generates the sort of probabilistic differentiation observed in D. discoideum we first incorporated the deterministic influence of the cell cycle on responsiveness or ...

Sorting cells with target metabolic functions from a mutant pool exhibiting substantial genetic diversity is often the rate-limiting step in synthetic biology. Here, we developed a label-free, ...

ESC colonies expanded in EMM were homogeneously undifferentiated (Appendix Fig. S2E), and consistent with the smaller size of EMM colonies, we observed that ESCs grown in these conditions have a ...

The process of necrosis, a form of cell death, may represent one of the most promising ways to change the course of human aging, disease and even space travel, according to a new study.