The absence of oxygen and glucose during an ischemia event triggers anaerobic metabolism, resulting in lactate accumulation and an increase in Lactate dehydrogenase (LDH) activity. Thus, in order to ...

In hypoxia or intense glycolysis, pyruvate is reduced to lactate by LDH Lactate is subsequently converted to Lactyl-CoA, facilitating lactylation of histones and non-histone proteins, potentially ...

Extract: In nine experiments with sheep, effects of hypoxia on levels of lactate, pyruvate, and glucose in maternal and fetal blood were strudied. Bolld samples were obtained simlultaneously from ...

Department of Biochemistry, University of Utah, Salt Lake City, USA Department of Human Genetics, University of Utah, Salt Lake City, USA Howard Hughes Medical Institute, University of Utah School of ...

The authors show that increased pyruvate import into the mitochondria in liver-like cells and in primary hepatocytes drives gluconeogenesis but reduces cellular amino acid production, suppressing ...

This month's cover highlights the article Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis by Tobias Ackermann, Saverio Tardito and colleagues. The ...

1. HIF-1, as a transcription factor, enhances lactate production by regulating the expression levels of several key enzymes in glycolysis (HK, PGK, PFK, LDH, PDH and PKM2) and the glucose transport ...

pyruvate carboxylase deficiency; VLCADD, very long chain acyl-CoA dehydrogenase deficiency. Adapted with permission from Ward JC. Inborn errors of metabolism of acute onset in infancy. Pediatr Rev ...

One test that may prove useful for the prehospital diagnosis of sepsis is lactate measurement. In a process called glycolysis, cells of the body convert glucose into a molecule called pyruvate ...