1. HIF-1, as a transcription factor, enhances lactate production by regulating the expression levels of several key enzymes in glycolysis (HK, PGK, PFK, LDH, PDH and PKM2) and the glucose transport ...

The absence of oxygen and glucose during an ischemia event triggers anaerobic metabolism, resulting in lactate accumulation and an increase in Lactate dehydrogenase (LDH) activity. Thus, in order to ...

Hyperpolarized [1-13 C] pyruvate experiments revealed distinct metabolic profiles for the two cell types, highlighting the bioreactor’s ability to discern metabolic profiles among samples. Our results ...

6-Biphosphatase 3 (PFKFB3), Pyruvate Kinase Isozyme Type M2 (PKM2), and the Lactate Dehydrogenase A (LDHA). These studies provide a novel perspective for GBM treatment. Despite progress made in ...

Runners are probably all too familiar with the feeling of lactate build-up – legs burning, general weakness, shortness of breath, potential cramping and even visible shaking of the muscle.