In hypoxia or intense glycolysis, pyruvate is reduced to lactate by LDH Lactate is subsequently converted to Lactyl-CoA, facilitating lactylation of histones and non-histone proteins, potentially ...

1. HIF-1, as a transcription factor, enhances lactate production by regulating the expression levels of several key enzymes in glycolysis (HK, PGK, PFK, LDH, PDH and PKM2) and the glucose transport ...

Extract: In nine experiments with sheep, effects of hypoxia on levels of lactate, pyruvate, and glucose in maternal and fetal blood were strudied. Bolld samples were obtained simlultaneously from ...

Venous blood lactic acid and pyruvic acid concentrations and lactate-pyruvate ratio were studied in 42 normal adults, 16 normal children and 18 children with congenital heart disease. There was ...

Venous blood lactic acid and pyruvic acid concentrations and lactate-pyruvate ratio were studied in 42 normal adults, 16 normal children and 18 children with congenital heart disease. There was ...

In a subsect of pleural effusions, there is discordance between protein and lactate dehydrogenase (protein high, LDH low or vice versa). The causes of this biochemical pattern are not well established ...

l-Lactate oxidase is immobilised in a thin membrane placed over an electrochemical probe. The enzyme catalyses the conversion of l-lactate to pyruvate and hydrogen peroxide, the latter then being ...