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揭示线粒体 DNA 隐秘突变:衰老与疾病研究的新突破
隐秘突变达到生理相关水平且符合理论:研究人员借助群体遗传学的 Moran 模型和 Kingman 合并模型进行模拟和理论推导,通过贝叶斯推断拟合模型,得出人类 mtDNA 的突变率约为 4.6×10-8 每碱基每复制,与文献相符。同时发现,随着年龄增长,细胞中同质性 ...
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