The kinetochore is a large proteinaceous structure that mediates interactions between chromosomal DNA and spindle-microtubule polymers. More than 80 kinetochore proteins have been identified using ...

Whitehead Institute scientists report that two proteins once thought to have only supporting roles, are the true "stars" of the kinetochore assembly process in human cells. "When you understand a ...

Whitehead Institute scientists report that two proteins once thought to have only supporting roles, are the true "stars" of the kinetochore assembly process in human cells. The kinetochore is ...

This is an essential protein that bridges the centromeric region to the outer proteins of the kinetochore. Researchers rebuilt CENP-C by "gluing" together the two ends of it.

The two proteins, KNL2 and CENP-C, are crucial for correctly separating chromosomes during cell division. They dock precisely onto the centromeric DNA, analogous to the "lock and key principle." ...

This is the function of the kinetochore, a conserved network of proteins that attach each chromosome to microtubule filaments during chromosome segregation. The kinetochore consists of two parts: the ...

While Aurora B is known to act by phosphorylating the kinetochore protein Ndc80, Mps1 had been reported to phosphorylate another protein – Spc105. The authors tested which of these proteins was needed ...

In the process, they have discovered how the different kinetochore proteins work together to bind the chromosomes securely to the microtubules. Cell division is vital for the continuation of life.

Scientists report that two proteins once thought to have only supporting roles, are the true "stars" of the kinetochore assembly process in human cells. The kinetochore is vital to proper DNA ...

Mitosis, the mechanism of cell division that is so important for life, involves more than 100 proteins at its core. The group of Professor Andrea Musacchio from the Max Planck Institute of ...