Rita P.–Y. Chen. "Our results demonstrate how a simple chemical modification—phosphorylation—can fundamentally alter tau's behavior in cells, offering new insights into the early events of ...

Phosphatase enzymes are challenging to study due to a lack of specific inhibitors. Here, authors develop a chemical-genetic system to inhibit and characterize a major Ser/Thr phosphatase complex ...

在植物免疫研究中，SOBIR1 作为 RLP 介导免疫的共受体，其稳态和活性调控机制不明。研究人员开展了关于 SOAK1 与 SOBIR1 相互作用及对植物免疫调控的研究，发现二者相互磷酸化形成反馈回路，精细调控 RLP 介导的植物免疫，为植物免疫机制研究提供新视角。 在 ...

They identified that both proteins interact together and that MARK2 phosphorylates CAMSAP2 on the residue S835. They show that the phosphorylation affects the localisation of CAMSAP2 at the Golgi ...

CAMSAP2, GM130 and MARK2 are enriched in the Golgi fraction of RPE1 cells and MARK2 knockdown cells (GM130, Golgi). MARK2 phosphorylation of serine at position 835 of CAMSAP2 affects the localization ...

Department of Chemistry, University of Pennsylvania, 231 S. 34th St., Philadelphia, Pennsylvania 19104, United States ...