When the macrophages’ ability to consume dying cancer cells or Upd3 production was decreased, tumor growth was significantly ...

When cancer cells die, macrophages consume them and produce inflammatory cytokines. This activates JAK and STAT proteins in ...

When cancer cells die, macrophages consume them and produce inflammatory cytokines. This activates JAK and STAT proteins in ...

Scientists at Nagoya University in Japan studied what happens when macrophages—a type of immune cell—encounter dying cancer ...

Scientists at Nagoya University in Japan studied what happens when macrophages—a type of immune cell—encounter dying cancer cells in tumors and ...

2025年5月，胡琼依副研究员在Blood【IF21.1，Q1】杂志在线发表题名为“Ruxolitinib Targets JAK-STAT Signaling to Modulate Neutrophil Activation in Refractory Macrophage ...

鲁索利替尼通过广泛抑制 jak-stat 信号、调控中性粒细胞活化及 netosis，为难治性 aosd-mas 患者提供了显著的临床疗效，为这类危及生命的炎症性疾病开辟了新的治疗方向。同时，研究发现的 jak-stat 通路功能性变异位点，为未来个体化治疗策略的开发奠定了基础。

研究人员针对 JAK/STAT 信号通路与铁死亡（Ferroptosis）的关系展开研究，发现其在多种疾病中作用关键，为治疗提供新思路。 铁死亡（Ferroptosis），一种近年来备受瞩目的调节性细胞死亡方式，因其在癌症、神经退行性疾病等多种 ...

The JAK-STAT pathway is critically involved in the pathogenesis of myeloproliferative neoplasms, including myelofibrosis (MF), making it a central focus for therapeutic intervention. Targeting this ...

Hu, X.Y., et al. (2021) The JAK/STAT Signaling Pathway From Bench to Clinic. Signal Transduction and Targeted Therapy, 6, Article No. 402. ... Current investigations show that macrophages have ...

Macrophages were then polarized as inflammatory macrophages (by LPS + IFNγ, or GM-CSF), or as alternative macrophages (by IL-4, or IL-10), in the presence or not of JAKi ... (in the presence of IL-4 ...