Previous approaches didn't provide sufficient resolution to let researchers accurately detect the association and dissociation of protons to and from individual amino-acid residues in real time.

D-amino acids were originally thought to be unnatural ... The new enhanced mass spectrometry technique of PIESI (Paired Ion Electrospray Ionization) was developed in his laboratory and is one ...

Amino acids are generally not very amenable to direct detection by LC-MS due to their low ionization efficiency. Therefore, derivatization is often performed to improve their detectability and ...

In a study published in 2005, the Grosman lab showed that ionizable amino acids (that is, those that may alternately be charged or neutral) can be engineered into the inner lining of the channel pore.

“MS is an amazingly powerful technique that can easily resolve the mass differences between the amino acids, and it employs detectors that can measure single ions. The problem lies with electrospray ...