Ion channels play a pivotal role in signal ... enhancing spontaneous slow inward currents (SICs) and inducing central sensitization and mechanical allodynia. BDNF alleviates hyperalgesia by activating ...

Potassium channels are ion channels that are selective for passage of potassium ions through the pore. Potassium channels are homotetramers and are crucial for membrane hyperpolarization events ...

For this article, author Jennifer Fisher Wilson interviewed Roderick MacKinnon, Howard Hughes Medical Institute investigator and head of the Laboratory of Molecular Neurobiology and Biophysics at ...

Image: Courtesy of Roderick MacKinnon MAPPING THE PATH: The transmembrane pore of K+ channels is composed of four identical subunits, of which two are shown. The ion pathway contains a narrow ...

Cite this: Targeting Ligand-gated Ion Channels in Neurology and Psychiatry: Is Pharmacological Promiscuity an Obstacle or an Opportunity? - Medscape - Mar 02, 2010.

The rpTx1-induced persistent currents were inhibited by tetrodotoxin (TTX), a central pore blocker of TTX-S Nav channels (Fig. 1C, lower panel), indicating that the non-inactivated currents were ...

Channelopathies encompass a diverse group of diseases characterized by abnormalities in ion currents without any structural defects in the heart. These diseases can arise from genetic polymorphisms or ...

Voltage-dependence gating of ion channels underlies numerous physiological and pathophysiological processes, and disruption of normal voltage gating is the cause of many channelopathies. Here, long ...

A group of genes which are linked to the susceptibility of NIHL had been uncovered, involving the progression of oxidative stress, potassium ion cycling, cilia structure, heat shock protein 70 (HSP70) ...