Cite this: Targeting Ligand-gated Ion Channels in Neurology and Psychiatry: Is Pharmacological Promiscuity an Obstacle or an Opportunity? - Medscape - Mar 02, 2010.

The rpTx1-induced persistent currents were inhibited by tetrodotoxin (TTX), a central pore blocker of TTX-S Nav channels (Fig. 1C, lower panel), indicating that the non-inactivated currents were ...

Channelopathies encompass a diverse group of diseases characterized by abnormalities in ion currents without any structural defects in the heart. These diseases can arise from genetic polymorphisms or ...

Voltage-dependence gating of ion channels underlies numerous physiological and pathophysiological processes, and disruption of normal voltage gating is the cause of many channelopathies. Here, long ...