Membrane proteins have crucial roles in signaling and as anchors for cell ... sensitive intracellular control protein. Here we provide a detailed protocol for determining extracellular ...

Many proteins ... extracellular region of membrane proteins have primarily involved PPI analysis using molecules with cellular toxicity, prompting a search for systems targeting living cells.

Membrane proteins can allow hydrophilic molecules to pass through the cell membrane ... the ECM to mediate changes that occur in extracellular and intracellular environments.

On the other hand, when cells ... synaptotagmin proteins have been widely known for their role in controlling and regulating the union of intracellular vesicles with the plasma membrane.

Exosomes are a type of nanometer-sized extracellular vesicles that originate through budding from the plasma membrane ... like therapeutic proteins and gene editors into cells.

The new research, published in Nature Communications, identified protein ... changes in the cell membrane tension, facilitating activation of Tmem63b with increase in intracellular calcium.

This graphic illustrates paracrine adhesion signaling on small extracellular vesicles, which secretes a protein called galectin-3, which promotes endocytosis so the vesicle can be absorbed into ...

They were able to see areas of the membrane called focal adhesions, which allow the cell to migrate. "These are effectively the feet of the cell," explained Kusumi. Within the focal adhesion are ...

Researchers at Karolinska Institutet have developed a technique that enables efficient delivery of therapeutic proteins and RNA to cells ... of extracellular vesicles for efficient intracellular ...

Proteins tend to fold wrongly and ... may result from misfolded protein accumulation inside (intracellular) or outside (extracellular) cells. A set of unique proteins—molecular chaperones ...