The key lies in extracting the relationship between the signals inside the cells (intracellular signals) and those recorded on their surface (extracellular signals). "We discovered that ...

In summary, a growing number of studies show that extracellular control of TGFβ signalling is vital for both development and maintenance of the vasculature. The intracellular mechanism of ...

Uniting our strengths in cell biology, molecular biology, physiology, and pathology, producing a genuinely translational approach to medicine. The Division of Digestive Diseases aims to change ...

Department of Chemistry, Saint Louis University, Saint Louis, Missouri 63103, United States Institute for Drug and Biotherapeutic Innovation, Saint Louis University, Saint Louis, Missouri 63103, ...

This important work identifies a non-autophagic role for ATG5 in lysosomal repair and the trafficking of the glucose transporter GLUT1 to the cell surface, mediated through the retromer complex. The ...

Digestion begins in your mouth. Your teeth grind the food you eat and mix it with saliva to form a kind of ball, known as a bolus. Your esophagus is a flattened muscular tube that connects your mouth ...

Thus, we expect that this approach will provide a standardized tool for rapid development and testing of new anti-tumor treatments. The newly developed cultures that incorporate an extracellular ...