These actions are induced by hormone binding extracellularly to the ANP receptor 1, thereby activating its intracellular guanylyl cyclase domain for the production of cyclic GMP 2. Here we present ...

Bone growth occurs through the proliferation of specialized cells of the cartilage tissue, known as chondrocytes, on either ...

Bone growth occurs through the proliferation of specialized cells of the cartilage tissue, known as chondrocytes, on either ...

Figure 1: Targeted disruption of the Trβ2 exon. Figure 2: Expression of Trβ2 in eye development. Figure 3: Absence of M-cones and altered distribution of S-cones from Trβ2-deficient mice ...

Semaglutide, a synthetic analog of glucagon-like peptide-1 (GLP-1), has garnered attention for its intriguing properties and potential implications in various r ...

Guanylyl cyclase C (GCC) is the receptor for the family of guanylin peptides and bacterial heat-stable enterotoxins (ST). The receptor is composed of an extracellular, ligand-binding domain and an ...

Contribution from the Program in Chemistry and Chemical Biology, Departments of Pharmaceutical Chemistry and Cellular and Molecular Pharmacology, University of California, San Francisco, California ...

Vaccines have had a major impact on the control of infectious disease, most recently by helping to combat the COVID-19 pandemic. Prophylactic cancer vaccines have prevented several malignancies by ...

Here, we demonstrate that Drosophila malignant epithelial tumors show a similar reduction in ecdysone signaling, the main steroid hormone pathway. Our analysis of ecdysone-induced downstream targets ...

This trial was looking at a drug called AZD8931 for breast cancer. It was for post menopausal women with breast cancer that was locally advanced, or had spread to another part of the body, and was ...

Bone growth occurs through the proliferation of specialized cells of the cartilage tissue, known as chondrocytes, on either end of a bone. This ...