† Department of Chemistry, Infection Innovative Medicines Unit, AstraZeneca-US, 53 Gatehouse Drive, Waltham, Massachusetts 02451, United States ‡ Department of Biosciences, Infection Innovative ...

While hypolipidemia characterizes VL, LD, a cholesterol auxotroph, relies on host lipid scavenging for its intracellular survival. The aggressive pathology, in terms of increased organ parasite load, ...

The sand flies feed on the infected blood, taking amastigotes, and the lifecycle continues in a circular fashion (7). Moreover, this intracellular amastigote is a target for host immunity and ...

We observed a significant increase in both the percentage of infected MΦs (at least one LD/MΦ) and the number of intracellular amastigote counts after 4 h of co-incubation with 50 μM of r-KMP-11 as ...

Abstract: In the field of biomedicine, electroporation-mediated intracellular drug delivery is becoming increasingly popular due to its high efficiency and accuracy. In order to assess the therapeutic ...

Cell membranes are barriers that maintain cellular homeostasis, and the intracellular delivery of biologically functional molecules, including peptides, proteins, and nucleic acids to manipulate ...

Disease-relevant targets of infection by obligatory intracellular pathogens are beyond the reach of conventional antibodies. The neutralizing targets of intracellular pathogens in host cells are ...

Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana 500046, India ...