"In both diseases, cells suffer from toxic protein buildup. It appears there is a common mechanism that gets rid of these proteins to prevent them from clustering. NU-9 is rescuing the pathway ...

Overexpression of HDAC6 in mice results in a significant thickening of the corneal epithelium. Mechanistic studies reveal that HDAC6 overexpression disrupts mitotic spindle orientation and positioning ...

Interphase and prophase, 91 cells; prometaphase ... or 10 μM Thioflavin T (ThT) in the medium to label cells for about 30 min in the incubator before imaging. For ThT staining, about ten percent ...

We have included images to show that BiP co-localizes with ER-FlucDM-eGFP aggregates in interphase cells (Figure S5C). We think that BiP participates in the formation of ER-FlucDMeGFP during ...

We offer services using the best available mass spectrometry-based proteomics techniques and methods with focus on quantitative proteomics, including single cell proteomics. This new book presents a ...

Background and aim: Alkaline sphingomyelinase (NPP7) is expressed by intestinal epithelial cells and is crucial for the digestion of dietary sphingomyelin. NPP7 also inactivates proinflammatory ...

ACDC then converts the marker matrix into landmark points which represent cellular population’s fingerprints, and the semi-supervised learning algorithm is implemented through a random walk process ...

In summary, by introducing hundreds of specific and non-repetitive sgRNAs in a human cell, we are able to paint an entire chromosome in a live cell for fluorescent imaging. We have visualized the ...