The three-signal paradigm tries to capture how the innate immune system instructs adaptive immune responses in three well-defined actions: (1) presentation of antigenic peptides in the context of MHC ...

Recent developments in the field include an evolving treatment landscape and the development of evidence-based guidelines.

Summary: Tocilizumab is a novel monoclonal antibody that competitively inhibits the binding of interleukin-6 (IL-6) to its receptor (IL-6R). Inhibiting the entire receptor complex prevents IL-6 ...

The FDA's approval is grounded in an evidence totality and comprehensive data package, which includes outcomes from a study.

Investigative therapies to treat moderate to severe plaque psoriasis in clinical trials include several orally administered ...

To demonstrate the efficacy of targeting interleukin 6 receptor in patients with Sjögren’s syndrome-related systemic complications. Methods Multicentre double-blind randomised placebo-controlled trial ...

A study of adolescents found that individuals with low levels of emotional clarity who also exhibited higher levels of the inflammatory markers interleukin-6 and C-reactive protein were more likely to ...

Long-term treatment with lebrikizumab may be beneficial for patients with atopic dermatitis that were not initially ...

Data from a retrospective multicenter study, along with a review of previous trials, supported the real-world utility of ...

Serum soluble interleukin-2 receptor (sIL-2R) levels have been a great diagnostic tool for non-Hodgkin lymphoma (NHL) and ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...