Periodontal regeneration faces multiple challenges, the most important being cellular insufficiency. In an attempt to improve defect cellularity, we aimed to demonstrate enhancing cellular attraction ...

a key member of the integrin family. The signals underlying the spatial: key techniques evolving cancer research Shiva Malek discusses the techniques she uses to investigate cancer cell signaling and ...

The existence of alternative splicing forms of the messenger RNA of some integrins further increases the diversity within the integrin family. Despite the existence of previous research examining β1 ...

After arrest, leukocyte adhesion is strengthened through integrin clustering and outside-in signalling that involves spleen tyrosine kinase (SYK), SRC kinases, phosphoinositide 3-kinase (PI3K ...

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Here, we present the synthesis of highly active RGD peptidomimetics for the αvβ3 integrin with remarkable selectivity against α5β1. Incorporation of a methoxypyridine building block into a ligand ...

mAbs against human ICAM-1 (84H10), VCAM-1 (1G11), α 4 integrin subunit (HP2/1), desmin (77), and α-smooth muscle actin (IA4) were purchased from Immunotech. The cell type–specific mAbs against human T ...

A mixture of SHK, EPC, CHol, DSPE-PEG2000 and DSPE-PEG2000-RGD (weight: 30, 6, 3, 3, and 0.5 mg, respectively) was prepared into RGD-modified liposomes encapsulated with shikonin (RGD-Lip-SHK) using ...

常见的如 RGD（Arg - Gly - Asp）序列是与整合素结合的关键位点 。以含有 RGD 序列的整合素结合肽为例，精氨酸（Arg）、甘氨酸（Gly）和天冬氨酸（Asp）形成 RGD 核心序列，该核心序列对于与整合素的结合至关重要。同时，其周边的氨基酸残基如天冬酰胺（Asn）、脯 ...