To determine the apoptosis and necrosis status of the EBs formed under representative conditions, we quantified the viability of cells after 2 days of EB formation. Annexin V (an early apoptosis ...

The applications illustrated in this tutorial highlight the promise of human iPSC-derived cardiomyocytes to provide a human in vitro test system with cross-platform functionality in a biologically ...

Human induced pluripotent stem cells (iPSCs) bring human biology into pre-clinical aspects of drug discovery. iPSC-derived cardiomyocytes have emerged as useful tools for detecting and predicting ...

In vivo, male C57BL/6J mice were subjected to transverse aortic constriction (TAC) to induce cardiac hypertrophy, while in vitro experiments involved the treatment of cultured cardiomyocytes with ...

The inability to generate mature cardiomyocytes has hindered the development of cell therapy for heart disease as well as the generation of cells for the in vitro study of cardiac physiology and ...

Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes represent a promising model for in vitro prediction of cardiac arrhythmias. Currently, two commercially available hiPSC-derived ...

today announced that its human induced pluripotent stem cell (iPSC)-derived ventricular cardiomyocytes have undergone comprehensive in vitro pro-arrhythmia assay (CiPA) validation. Using this ...

"We have several pharmaceutical customers who've validated in vitro cardiotoxicity assays using iCell Cardiomyocytes, which have correlated well with previous data from cardiotoxicity studies in ...

4U® human iPSC-derived cardiomyocytes within assays that investigate the safety of drug compounds. Under the agreement, the FDA will perform in vitro experiments with Cor.4U® human iPSC ...

This offers a physiologically relevant in vitro research model of human heart cells to reliably and repeatably test drug candidates for cardiotoxicity at scale. With the advent of human iPSC-derived ...