Scientists have sorted out another piece of the DNA replication puzzle by showing what might happen to histones through the process of unwinding DNA. The linkurl ...

2024.07.017]. The scientists determined that Mrc1 and Mcm2 form a co-chaperone complex, ensuring distribution of histones to the lagging strand during DNA replication. In mutants of Mrc1 ...

Chances are you've seen an illustration of DNA's double-helix structure and even pictures of the chromosomes ... The DNA is wrapped around histones -- protein structures that are sometimes ...

The histone chaperone, Asf1, coordinates the removal of histones from the chromatin to allow the replication machinery to move along the DNA, with the supply of new histones to reform the ...

"Essentially, all histones are going away during DNA replication and new histones, which are not modified, are coming in," said Alexander M. Mazo, Ph.D., professor of Biochemistry and Molecular ...

The mechanism of a peculiar type of heterochromatin, used by embryonic stem cells to silence 'parasitic' DNA-elements within the context of their highly dynamic pluripotent chromatin. Disclaimer ...

one that allows the DNA replication process itself to progress smoothly without resulting in DNA damage. DNA is normally coiled around proteins called histones, which when chemically modified at ...

By using the TALO8 system, we have identified a unique pattern of acetylations specifically on histones flanking an origin of DNA replication. Our analyses have revealed that the two classes of ...

Accumulating evidence has revealed that epigenetics is critical in understanding the basic molecular mechanisms that take place in chromatin (transcription, splicing, replication and DNA repair ...

The graphic shows images of a cell under mtDNA replication stress made using so-called Correlative Light and Electron Microscopy (for short: CLEM). The mitochondrial DNA (mtDNA, green) is ejected ...

both replication processes worked independently without interference. The mirror-image polymerase could also transcribe mirror-DNA into mirror-RNA, again at a glacial pace. The work is published ...

Dr. Charlton and Flury's experiments showed that, during DNA replication, Mrc1 operates as a central coordinator of parental histone inheritance by binding the tetramer formed from histones H3 and H4.