Of these, the causal involvement of 10 proteins was substantiated by external validation data. Consistent evidence for PCSK9 (proprotein convertase subtilisin/kexin type 9), IL6R (interleukin‐6R), ...

IL6 可通过经典信号通路（与膜结合的 IL6 受体（IL6R）结合）或 trans 信号通路（与可溶性 IL6 受体（sIL6R）结合）发挥作用，这两条通路都需要 IL6ST（gp130）共受体激活下游 JAK/STAT 信号。由于 hTERT RPE-1 细胞表达低水平的膜结合 IL6R，研究人员用 100 ng/mL sIL6R 和不同 ...

Correspondence to Dr Sizheng Steven Zhao, Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Science, School of Biological Sciences, Faculty of Biological ...

1 Department of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China 2 Institute of Digestive Diseases, Jiangsu University, Zhenjiang, China The incidence of gastric cancer ...

Chronic inflammation of the intestine is a significant risk factor in the development of colorectal cancer. The emergence of colitis and colorectal cancer is a complex, multifactorial process ...

Correspondence to Prof. Yukinori Okada, Department of Statistical Genetics, Osaka University School of Medicine Graduate School of Medicine, Suita, Osaka, Japan; yuki-okada{at}m.u-tokyo.ac.jp; Prof.