We identify direct mRNA targets of the translational repressor Pumilio, finding that mRNAs bound by Pumilio encode proteins enriched in synaptosomes. Pumilio differentially binds to RNA isoforms of ...

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

Using computational tools and virtual screening, researchers at the Center for Redox Processes in Biomedicine (Redoxoma) have ...

The lab of Dan Xu, PhD, assistant professor at The Hormel Institute, has published a groundbreaking study in Cell Metabolism, ...

Alzheimer’s disease, a devastating neurodegenerative disorder, is closely linked to the accumulation of tau protein in the brain. When tau becomes hyperphosphorylated, it forms neurofibrillary tangles ...

The findings could pave the way for new therapies targeting metabolic diseases like obesity and type 2 diabetes.

ABSTRACT: Background: Aging-induced cardiac hypertrophy and reduced skeletal muscle strength contribute to increased disease risk and life burden in the elderly. FNDC5 acts as a protective muscle ...

Promising Nonalcoholic Steatohepatitis Therapies such as AZD2693, Saroglitazar Magnesium 4 mg, Semaglutide (SEMA), Cilofexor ...

Long-read RNA sequencing of human microglia expands the catalog of mRNA isoforms in this important cell type and assists with the interpretation of genetic associations with Alzheimer’s disease ...

UMass Lowell Recognized as Top Research Institution with R1 Classification Read More ⁠ ...

Four isoforms of JAKs have been described: JAK1, JAK2, JAK3 and TYK2. Oral JAK inhibitors (JAKi) have been developed as synergic anti-cytokine therapy in IBD, showing different selectivity towards JAK ...