1Department of Pathology, Yale University School of Medicine, New Haven, Connecticut. 2Department of Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, Sotiria ...

Macroporous alginate scaffolds embedded with interleukin (IL)-2 and activating CD3/CD28 antibodies are used to transduce fresh T cells with lentiviral CAR constructs. CAR-T cells containing scaffolds ...

Chimeric antigen receptor (CAR) T-cell therapy ... into T cells, improving safety while preserving CAR function. Synthetic NOTCH receptors offer tighter control over CAR expression, and engineered ...

To address this, Tsyklauri et al. studied Tregs in laboratory mice which had been modified to have autoimmune diabetes, which is when the body attacks the cells responsible for producing insulin. The ...

This paper will be of interest to scientists in the field of T cell biology and immunometabolism. The data analysis is rigorous and the experiments performed are appropriate. The findings of the ...

There is a delicate balance of transcription factor expression, indicating T-cell plasticity. Th17 cells can co-express RORγt and T-bet mRNA ... interferon; NK: natural killer; IL-2R, interleukin-2 ...

CAR T cell approaches to effectively target AML and T-ALL without off-tumor effects on healthy myeloid or T cell compartments respectively are an unmet medical need. NKG2D-ligands are a promising ...

Patients with acute myeloid leukemia who relapse after stem cell transplantation have just a small chance of survival: doctors can give them additional donor T cells to fight the cancer, but only ...