Extracellular acidity is a common immunosuppressive feature of tumors. This study reveals that low pH suppresses T-cell functions and alters IL-2/IL-2R, mTORC1, and c-Myc signaling, as well as amino ...

Roche said Monday that its bispecific T cell engager Columvi improved survival in a Phase III lymphoma trial, clearing the drugmaker to seek a full, expanded label that could drive sales growth.

Here, we found that regulatory T cells (Tregs) integrate concurrent signaling initiated by IL-2 and IL-4 to generate a response divergent from the sum of the two pathways in isolation. IL-4 ...

We also examined the extent that each of the three signaling pathways known to be stimulated by IL-2/IL-15 (JAK-STAT, PI3K-AKT Ras-RAF/MAPK) were activated and involved in the telomerase expression in ...

Moreover, the addition of a proteasome inhibitor to cell cultures, conferred NOD Tregs the ability to retain Foxp3 expression. Herein, we provide evidence indicating a differential expression of SOCS3 ...

In examining the potential impact of the co-localization of IL-2 and VSMC, we discovered that IL-2 knockout mice exhibit a systemic loss of smooth muscle cells over time, causing aortic aneurysms and ...

Furthermore, at low antigen concentrations binary IL-2 expression safeguards by its spatial distribution selective ... Our computational model describes a population of T cells that can secrete IL-2 ...

To understand quantitatively how individual T cells respond to IL‐2, we experimentally measured and modeled IL‐2 binding to the IL‐2R and the subsequent phosphorylation response of STAT5 (Lin and ...

DKO T cells up-regulated CD25 expression and secreted normal amounts of IL-2 after antigen stimulation ... and cytoskeletal rearrangement. DKO T Cells Express IL-2 Receptor (IL-2R) and Secrete IL-2 ...