为解决继发性淋巴水肿病理机制及治疗难题，澳大利亚研究人员开展靶向 IGF1R 对小鼠继发性淋巴水肿影响的研究。结果发现 IGF1R 抑制剂 linsitinib 可限制其发展。该研究为淋巴水肿治疗提供新方向，值得科研人员一读。 淋巴水肿是一种让人十分困扰的疾病 ...

点击“蓝字”关注我们2025年3月14日，信达生物制药集团宣布，信必敏[替妥尤单抗N01注射液，重组抗胰岛素样生长因子1受体（IGF-1R）抗体]已正式获得国家药品监督管理局（NMPA）的批准，用于治疗甲状腺眼病。这意味着信必敏成为中国首个、全球第二 ...

NT219 in combination with EGFR antibody cetuximab (Erbitux) is currently entering a Phase 2 study for head and neck cancer REHOVOT, Israel, March ...

The authors identified the IGF1-IGF1R ligand-receptor pair as a factor involved in the macrophage-mediated induction of memory-like Th17 cells, as confirmed by experiments using an IGF1R inhibitor.

Following mouse studies, the authors suggest that the IGF1-IGF1R pathway might play a role in how macrophages influence T cells, potentially driving the pathology of pre-eclampsia. There is convincing ...

Purple Biotech’s NT219 is a first-in-class small molecule drug designed to target key cancer resistance mechanisms by degrading IRS1/2 and blocking IGF1R/IRS1 and STAT3 survival pathways.

Antibodies and related products are the fastest growing class of therapeutic agents. By analysing the regulatory approvals of IgG-based biotherapeutic agents in the past 10 years, we can gain ...

The transition from hibernation to early arousal was marked by up-regulation of immune-related genes (e.g., CXCL12, ITGA4, PIGR) and endocrine regulators (e.g., CDKN1A, DLL4, IGF1R), facilitating ...

The table below highlights all of the cell lines that are included in the analyses and the types that they are annotated as: ...

1 The Second School of Clinical Medicine, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China 2 Department of Endocrinology and Metabolism, Jiujiang Hospital of Traditional Chinese ...