本综述深入探讨了缺氧（Hypoxia）、肿瘤干细胞特性（Cancer Cell Stemness）与药物耐受性（Drug Resistance）之间的复杂关系，揭示了其在肿瘤治疗中的关键作用。 肿瘤微环境中的缺氧是实体瘤的常见特征，与肿瘤的侵袭性、复发和治疗耐受性密切相关。缺氧能够诱导 ...

lung cancer research has classically focused on molecular drivers of disease. One such pathway, the hypoxic response pathway, is activated by reduced local oxygen concentrations at the tumor site.

Therefore, hypoxia is generally associated with more aggressive cancers and poor patient outcomes, as it drives changes that ...

Antibiotics increase the gut oxygen levels and favor growth of harmful fungi. Chemically restoring intestinal gut hypoxia ...

The team's findings were published in the paper "Functional reprogramming of neutrophils within the brain tumor microenvironment by hypoxia-driven histone lactylation," from Cancer Discovery.

Conversely, stabilization of HIF1α by knocking out a negative regulator of HIF1α increased IFN-γ under hypoxic conditions. With regard to defense against cancer, the researchers found that ...

The team's findings were published in the paper "Functional reprogramming of neutrophils within the brain tumor microenvironment by hypoxia-driven histone lactylation," from Cancer Discovery.

Tumor hypoxia is known to be associated with a reduction in radio-response. [85,86] The EORTC is now planning a randomized Phase III study [107] in patients with locally advanced HPV/p16-negative ...

The team’s findings were published in the paper “Functional reprogramming of neutrophils within the brain tumor microenvironment by hypoxia-driven histone lactylation,” from Cancer Discovery.