Here, we found that PKM2, a rate-limiting enzyme of glycolysis, displayed nuclear translocation in astrocytes of EAE (experimental autoimmune encephalomyelitis) mice, an animal model of multiple ...

However, its role in autoimmune diseases is largely unknown. Here, for first time, we demonstrate the therapeutic effect of URA in an experimental autoimmune encephalomyelitis (EAE) animal model. Oral ...

Alumis has raised $259 million in Series C financing to support Phase III development of a potential rival to Bristol Myers Squibb and Takeda in autoimmune diseases. The California-based biotech is ...

Previous studies showed the involvement of the hypothalamic–pituitary–adrenal (HPA) axis to susceptibility to autoimmune diseases, including MS, and its best-characterized animal model, experimental ...

The role of stress effector systems in the initiation and progression of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), the most commonly used experimental model of MS, ...

Experimental autoimmune encephalomyelitis (EAE) is the most common model of multiple sclerosis (MS). This model has been instrumental in understanding the events that lead to the initiation of central ...

Here we show that genetic deletion of KOR exacerbates experimental autoimmune encephalomyelitis, whereas activating KOR with agonists alleviates the symptoms. KOR does not affect immune cell ...

R‐flurbiprofen treatment of experimental autoimmune encephalomyelitis in mouse models of multiple sclerosis prevented and attenuated relapsing‐remitting and primary progressive EAE, suggesting that ...

R‐flurbiprofen treatment of experimental autoimmune encephalomyelitis in mouse models of multiple sclerosis prevented and attenuated relapsing‐remitting and primary progressive EAE, suggesting that ...

Multiple sclerosis (MS) and its mouse model, experimental autoimmune encephalomyelitis (EAE), are inflammatory disorders of the central nervous system (CNS). The function of platelets in inflammatory ...