However, the high osmolarity of hypertonic saline relative to other plasma expanders confers an additional advantage. With an intact blood-brain barrier, hypertonic saline should pull edematous ...

The serum osmolarity can be used as a surrogate measure of the effect of therapy with either mannitol or hypertonic saline. The initial target is an osmolarity of 300 to 320 mOsm per liter ...

"More importantly, heterologously expressed TMEM63B is activated by hypertonic stimuli ... purified TMEM63B in liposomes exhibits osmolarity-gated currents. Finally, Tmem63b knockout mice have ...

The first-ever randomized controlled trial on babies with cystic fibrosis (CF) has found that treatment with inhaled hypertonic saline can improve breathing and lung health. The study involved 40 ...

Inhaled hypertonic saline acutely increases mucociliary clearance and, in short-term trials, improves lung function in people with cystic fibrosis. We tested the safety and efficacy of inhaled ...

Their results, which were published in The Lancet Respiratory Medicine, demonstrate that idrevloride in hypertonic saline is safe and associated with a significant improvement in lung function ...

Am J Health Syst Pharm. 2010;67(22):1920-1928. Due to the high osmolarity of hypertonic saline, infusion through a central line is preferred to minimize phlebitis. Most studies used a 7.5% ...