Bacteria can precisely adjust their membrane lipid compositions to control the biophysical properties of their membranes, which allows them to thrive in various physical environments. Here ...

A novel fluorescence method for determining the depth of Trp residues in membrane-inserted polypeptides is introduced. Quenching of Trp by acrylamide and 10-doxylnonadecane (10-DN) was used to measure ...

PURPOSEWe report phase I trial results for pasritamig, a first-in-class, T-cell–engaging bispecific antibody targeting human kallikrein 2 (KLK2) expressed on the surface of prostate cancer (PC) ...

Sodium dodecyl sulfate−polyacrylamide gel electrophoresis (SDS−PAGE) is a universally employed technique that separates proteins on the basis of molecular weight (MW). However, membrane proteins are ...

Bispecific T cell engagers (TcEs) that are able to simultaneously bind to epitopes on cancer cells and T cells are a versatile, highly potent, and economical immunotherapeutic tool ().TcEs are ...

OBX-115 engineered tumor-infiltrating lymphocyte (TIL) cell therapy with regulatable membrane-bound IL15 (mbIL15) in patients (pts) with immune checkpoint inhibitor (ICI)–resistant advanced melanoma: ...

DNA nanostructures are emerging as useful tools for this purpose. By attaching hydrophobic groups like cholesterol, which anchor them into the lipid membrane's hydrophobic core, scientists have ...

By attaching hydrophobic groups like cholesterol, ... Citation: New tool reveals how DNA nanostructures interact with cell membranes (2025, May 27) ...