9 D-60438 Frankfurt a.M., Germany Branch for Translational Medicine and Pharmacology, Fraunhofer Institute for Molecular ... epoxide hydrolase (sEH) pharmacophores led to the discovery of a dual 5-LOX ...

Department of Biological Chemistry, The Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205-2185, and Department of Biology, The Johns Hopkins University, Charles and ...

The molecules that form the foundation of life on Earth are as diverse as they are complex. Among these, carbohydrates play a ...

A genome-mining approach, combining bioinformatics analysis and chemical insight, is applied to extract an interesting new structure from an organism previously thought to have been exhaustively ...

Structure-based drug design is the design and optimization of a chemical structure with the goal of identifying a compound suitable for clinical testing — a drug candidate. It is based on ...

Using cryo-electron microscopy, which enables visualization of frozen molecular structures at high resolution, the team analyzed this unique complex at a resolution of 3.66 Å (less than a ...

Once the correct sequence is found, the filament creates a stable three-stranded structure called a displacement loop (or D-loop) and the process of 'strand exchange' occurs, but the mechanistic ...

The molecules that form the foundation of life on Earth are as diverse as they are complex. Among these, carbohydrates play a vital role as energy ...