Hyaluronan synthase 1, i.e. the HAS1 enzyme, is the least well known of the hyaluronan-producing enzymes, and yet its role in cancer malignity seems to be greater than previously thought.

We demonstrate that TGFβ potently stimulates hyaluronan synthesis via upregulation of hyaluronan synthase 2 (HAS2 ... using the EMT marker ZO-1. Furthermore, real-time PCR analysis of the ...

Hyaluronan synthase 1, i.e. the HAS1 enzyme, is the least well known of the hyaluronan-producing enzymes, and yet its role in cancer malignity seems to be greater than previously thought.

By intensive sequencing of the hyaluronan synthase 1 (HAS1) gene in malignant and normal cells from patients with WM, we have identified both types of mutation in HAS1 exons and introns.

Abstract and Introduction Aberrant Splicing of Hyaluronan Synthase 1 in Waldenström's Macroglobulinemia Genetic Variations in Genomic DNA Might Promote Splicing Within HAS1 Sequential Acquisition ...

While epilepsy is one of the most common neurological disorders—affecting approximately 1 percent of the population ... in each of the three hyaluronan synthase genes (Has1, Has2, Has3).

Hyaluronan synthase 1, i.e. the HAS1 enzyme, is the least well known of the hyaluronan-producing enzymes, and yet its role in cancer malignity seems to be greater than previously thought.

Their study has also identified that this process is mediated by the induction of hyaluronan synthase 3 (HAS3) expression. In Japan, cadmium is well known as the causative agent of Itai-itai ...

According to a recent University of Eastern Finland (UEF) study, elevated cell sugar concentrations increase the production of hyaluronan which, in turn, promotes cancer growth.