Hyaluronan-IN-1 是一种小分子化合物，具有特定的化学结构。其分子包含多个芳香环结构以及连接在环上的各类官能团 。具体而言，分子中存在含氮杂环，这些杂环与其他碳环通过化学键相连，形成了较为复杂的空间结构 。其中一些官能团，如羟基、羰基等 ...

Their study has also identified that this process is mediated by the induction of hyaluronan synthase 3 (HAS3) expression. In Japan, cadmium is well known as the causative agent of Itai-itai ...

is synthesized by 3 HAS isoenzymes (hyaluronan synthases 1-3) at the plasma membrane. Considering further the importance of HAS3 for smooth muscle cell and immune cell functions we aimed to evaluate ...

Hyaluronan synthase 2 (HAS2) deletion from fibrotic fibroblasts induces senescence (gradual deterioration) in the cells and fibrotic clearance in mouse models of lung fibrosis. The findings, reported ...

1 Department of Dermatology, Kuopio University Hospital, University of Eastern Finland, Kuopio, Finland 2 Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland Hyaluronan synthase 1 ...

In the new study, Prof Yamaguchi and his colleagues examined the role of hyaluronan using mutant mice deficient in each of the three hyaluronan synthase genes – Has1, Has2, Has3. “We showed that ...

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