The Huntington’s disease treatment market is evolving, with novel therapies targeting mHTT and reshaping the future of neurodegeneration. With the era of symptomatic treatment nearing its limits, ...

A University of California, Irvine-led research team has discovered intricate molecular mechanisms driving the RNA processing defects that lead to Huntington's disease and link HD with other ...

Potential new therapeutic targets for Huntington's disease Molecular mechanisms revealed that drive RNA processing defects leading to disorder Date: January 8, 2025 Source: University of ...

aDepartments of Psychiatry, Neurology, Pharmacology, and Neuroscience, and Program in Cellular and Molecular Medicine, Johns Hopkins University ... and cellular toxic effects involving both cell ...

Expansion microscopy reveals the structure of huntingtin aggregates inside the cell nucleus. Credit: © 2024 Korsten et al. Originally published in the Journal of ...

Huntington’s disease (HD) is a paradigm of a genetic neurodegenerative disorder characterized by the expansion of CAG repeats in the HTT gene. This extensive review investigates the molecular ...

At first, Huntington’s disease patients have mild symptoms ... with which to investigate questions of the molecular mechanisms triggered by disease genes. As the saying goes, it takes a village ...

These issues tend to manifest in an individual's 30s or 40s, and the disease is fatal within ten to thirty years of the initial appearance of symptoms. Scientists have now discovered a neural circuit ...

SANTA FE, N.M., & NEW YORK, N.Y. – OpenEye Scientific (OpenEye) and CHDI Foundation (CHDI) today announced a research collaboration to identify novel small-molecule therapeutics for Huntington’s ...

Osama Al-Dalahmah from the Department of Pathology and Cell Biology at Columbia University, provide an in-depth perspective on Huntington’s disease (HD) research Huntington’s disease ... it has not ...

Symptoms of Huntington’s disease involve motor and cognitive skills. After they begin, the effects gradually worsen. Sometimes, early on, the symptoms of Huntington’s disease can be similar to those ...

The identification of this molecular mechanism sheds light on the ... "The benefits of this study in a disease such as Huntington's, associated with a genetic mutation, is that we can analyze ...