Mitogen‐activated protein kinase (MAPK) cascades are highly conserved signaling modules consisting of MAPK Kinase Kinases (MAPKKKs/MEKKs), MAPK Kinases (MAPKKs/MKKs/MEKs), and MAPKs/MPKs, which are ...

Recent research has shown that the interaction of sphingosine-1-phosphate with its receptors (S1PR1–S1PR5) has an essential role in regulating immune responses, not only through the control of ...

Background Immune responses on SARS-CoV-2 vaccination in patients receiving anti-CD20 therapies are impaired but vary considerably. We conducted a systematic review and meta-analysis of the literature ...

Evidence for autocrine endothelial apelin signaling came from a study demonstrating that apelin preserves endothelial integrity in models of immune‐mediated vascular injury. 76 Alloimmune‐mediated ...

The immune molecule STING has been identified as a key driver of brain inflammation, amyloid plaque, and tau tangle formation in Alzheimer's disease. Blocking STING in mice reduced neuronal damage ...

The innate immune system senses invariant microbial components via toll-like receptors (TLRs) to elicit a host defense program against invading pathogens. Lipopolysaccharide (LPS), a constituent of ...

Citation: Fineschi S, Klar J, Lopez Egido JR, Schuster J, Bergquist J, Kaden R and Dahl N (2025) Comprehensive transcriptome assessment in PBMCs of post-COVID patients at a median follow-up of 28 ...

The analysis revealed that PGD2 mediates its tumor-suppressive effects by activating immune cells, particularly NK/T cells, which could be important for modulating anti-tumor immune responses. Our ...

Background: Despite the wide availability and cost-effectiveness of chest X-rays (CXRs), their potential as a biomarker for immune checkpoint inhibitor (ICI) response in non-small cell lung cancer ...