Unfortunately, regenerative potential of the adult heart is limited. The Hippo pathway is a recently identified signaling cascade that plays an evolutionarily conserved role in organ size control by ...

We identified three ubiquitin ligases – RNF146, TRAF3, and PHF5A – as potential negative regulators for the Hippo pathway from the primary screen using the luciferase reporter (Supplemental Table 3 ...

Inhibition of MAP4K kinases reduced Hippo pathway activity. HEK293A cells were treated with GNE‐495 (inhibitor of MAP4K kinases) at 0, 1, 5, or 10 μM for 24 h. Phosphorylation of LATS1 (HM), NF2 (S13, ...

Vivace Therapeutics, Inc. today announced that the first clinical data for a cancer treatment targeting the Hippo pathway will be presented at the American Association for Cancer Research (AACR) ...

The Hippo pathway is mainly composed of mammalian serine/threonine (Ste20)like kinases 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and transcriptional coactivator Yes-associated protein (YAP), ...

Here, studies demonstrate that NGF inhibits the Hippo signaling pathway and activates Yes-associated protein (YAP) to induce cervical cancer cell proliferation and migration. Our results suggested ...

Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China ...

They discovered that during development, when progenitor heart cells progressively differentiate into various cell types, the Hippo pathway is essential to coordinate the development of these cell ...