The Hippo pathway, which controls tissue growth, and proteins that regulate apicobasal polarity have separately been implicated in renal cystogenesis. New research by Thomas Weide, Hermann ...

Unfortunately, regenerative potential of the adult heart is limited. The Hippo pathway is a recently identified signaling cascade that plays an evolutionarily conserved role in organ size control by ...

1 Department of Cell Systems and Anatomy, The University of Texas Health San Antonio, San Antonio, TX, United States 2 Department of Obstetrics, The Second Xiangya Hospital, Central South University, ...

这篇综述深入探讨了Hippo通路下游效应因子YAP/TAZ在神经系统中的多维度调控机制，系统梳理了其在神经发育、突触可塑性 ...

The reported tool, DIPx, could be of use for personalized drug synergy prediction and exploring the activated pathways related to the effects of drug combinations. Targeted monotherapies for cancer ...

Genome-wide DNA binding profiles and biochemistry data reveal that E75 not only binds to the transcription factors of both Hippo and Notch pathways, but also exhibits widespread co-binding to their ...

Here, we demonstrate that inhibition of the p38 MAPK-MK2 signaling pathway sensitizes cancer cells to MTA treatment. We utilize CMPD1, a dual-target inhibitor, to concurrently suppress the p38-MK2 ...

1 Department Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany 2 Clinic and Polyclinic of Psychiatry and Psychotherapy, Bonn University Clinic, Bonn, Germany ...

The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States Division of Molecular Biophysics & Integrated Bioimaging, Lawrence Berkeley National Laboratory, ...