There has been some concern with starting warfarin without concomitant heparin. This is due to the fact that two vitamin K dependent factors, protein C and protein S, are natural anticoagulants ...

Fibroblast growth factor 2 (FGF-2), an important paracrine growth factor, binds electrostatically with low micromolar affinity to heparan sulfates present on extracellular matrix proteins. A single ...

Sulfated glycosaminoglycans have a vast range of protein interactions relevant to the development of new biomaterials and pharmaceuticals, but their characterization and application is complicated ...

As these medications are more broadly adopted, 15, 16 ongoing evaluation of their effectiveness and safety is important. Until observational studies confirm the generalizability of the clinical trials ...

Heparin or LMWH should be discontinued 12 hours before planned induction of labor. Heparin or LMWH should be started postpartum and overlapped with warfarin for 4 to 5 days. There is convincing ...

The quality of the warfarin treatment has in several studies been shown to be of utmost importance in patients treated with warfarin due to atrial fibrillation (AF).6 In patients with AF with high ...

Chakravarti et al. managed anticoagulation for 11 patients undergoing 12 TURP procedures by stopping warfarin and then starting intravenous unfractionated heparin 2 days preoperatively; the ...

Introduction Pre-eclampsia is an important cause of death and complication for pregnant women and perinatal infant. Low-dose aspirin has been most commonly used to prevent pre-eclampsia in high-risk ...