In adult mammals, the process of hematopoiesis starts with quiescent and self-renewing hematopoietic stem cell (HSC) population (Pietras et al, 2015).Tightly regulated quiescence, along with ...

Scientists at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, have found that gene editing using CRISPR-Cas9 in combination with AAV6 vectors can trigger inflammatory and ...

The U.S. health secretary said people should have access to experimental therapies including unregulated uses of stem cells. But some methods have resulted in blindness, tumors and other injuries.

The researchers found that in newborn mice—and up to two weeks after birth—there are significantly more hematopoietic stem and progenitor cells (HSPCs) in circulation compared to older animals. This ...

From mixed to matched: new marker pinpoints therapeutically relevant stem cell–derived islets Human pluripotent stem cell–derived islets hold great promise as a functional cure for diabetes.

Scripps’ lung medicine activates stem cells in the lower airways, known as type 2 alveolar epithelial (AEC2) cells, responsible for manufacturing crucial cells for exchanging stale oxygen for fresh.

More information: Senescence and inflammation are unintended adverse consequences of CRISPR-Cas9/AAV6 mediated gene editing in hematopoietic stem cells, Cell Reports Medicine (2025). DOI: 10.1016 ...

Ernexa Therapeutics’ “Trojan Horse” stem cells can infiltrate ovarian tumors in mice, boosting T cell activity and leading to shrunken tumors and improved survival, the company announced in ...

Baccarella A, Patel T, Conrad MA, et al. Outcomes of allogeneic hematopoietic stem cell transplant in monogenic inflammatory bowel disease. Clin Gastroenterol Hepatol . Published online May 14 ...

Angiogenesis is crucial to improving neurovascular remodeling poststroke. Therein, the transformation of endothelial cells (ECs) to tip cells is essential in initiating angiogenesis. Mitochondrial ...