Assembly Bio has advanced both ABI-5366 and ABI-1179 into Phase 1b studies after each long-acting helicase-primase inhibitor candidate exceeded the company’s target PK profiles in Phase 1a ...

(Nasdaq: ASMB), a biotechnology company developing innovative therapeutics targeting serious viral diseases, today announced that the first participant has been dosed in the Phase 1b portion of the ...

HSV helicase-primase inhibitors target the viral helicase-primase complex, an essential viral enzyme complex that is conserved across both HSV-1 and HSV-2 and has no host equivalent.

The helicase was observed to bind the DNA in a cyclic motion, pulling the tracking or leading strand through binding loops while directing the non-tracking or lagging strand out of the complex.

SOUTH SAN FRANCISCO, Calif., June 30, 2025 (GLOBE NEWSWIRE) -- Assembly Biosciences, Inc. (Nasdaq: ASMB), a biotechnology company developing innovative therapeutics targeting serious viral diseases, ...

It follows a previous report showing that the Werner syndrome protein WRN and its interacting protein WRNIP1 are indispensable for translesion DNA synthesis (TLS) by Y-family DNA polymerases (Pols).

P68 RNA helicase regulates the alternative splicing of the important proto-oncogene H-Ras, and numerous studies have shown that p68 RNA helicase is probably involved in miRNA biogenesis, ...

Dr. Shahid continued: "The helicase mechanism we've uncovered appears to be evolutionarily conserved from viruses to humans, providing a universal blueprint for understanding DNA replication ...

IDEAYA Biosciences Announces IND-Clearance for Werner Helicase Development Candidate IDE275 (GSK959) for a Phase 1 Study in MSI-High Solid Tumors PR Newswire Mon, Oct 28, 2024, 6:00 AM 5 min read ...

Ideaya Biosciences Inc. has announced FDA clearance of an IND for a GSK-sponsored phase I/II trial of GSK-101 (IDE-705), a small-molecule inhibitor of Polϴ helicase, in combination with GSK's PARP ...

Assembly Biosciences Inc. has selected development candidate ABI-5366 to progress to IND-enabling studies from its long-acting herpes simplex virus type 2 (HSV-2) helicase inhibitor program for ...

Different RNA helicases, particularly those in the dead box helicase (DDX) family, are dysregulated in cancer; however, there have been very few attempts to produce small molecule inhibitors.