Transient gene editing of the herpes simplex virus type 1 (HSV-1) using mRNA-based CRISPR was shown for the first time to be effective against herpetic stromal keratitis (HSK) in mice and blocked ...

When the researchers tested various gRNAs targeting different essential HSV-1 genes in conjunction with CRISPR/Cas9, they found that many of them were able to reduce virus replication.

More information: Herpes simplex virus-1 evades APOBEC1-mediated immunity via its uracil DNA glycosylase in mice, Nature Microbiology (2025). DOI: 10.1038/s41564-025-02026-3 Provided by University ...

Herpes simplex virus type 1/adeno-associated virus (HSV/AAV) rep+ hybrid amplicon vectors containing AAV inverted terminal repeats (ITRs) and rep gene sequences can mediate site-specific ...

Infections caused by herpes simplex virus type 1 (HSV-1) ... When mice received this AAV-UGI vector before exposure to HSV-1, they were far more likely to survive. Related Stories.

Infectious disease researchers at Fred Hutchinson Cancer Research Center have used a gene editing approach to remove latent herpes simplex virus 1, or HSV-1, also known as oral herpes.

Finally, they tested the adapted CRISPR/Cas9 tool on lymphoma cells infected with HSV-1. Despite the rapid replication of this virus – relative to HCMV – the team found that certain gRNAs ...

Researchers from Excision Biotherapeutics Inc. and affiliated organizations have reported the development of a novel CRISPR/Cas9-mediated genome editing therapy – EBT-104 – for the treatment of latent ...

One poster at the meeting will describe an nrHSV-1 vector containing two different transgenes controlled by independent regulatory elements in different epigenetic regions of the HSV-1 genome.